Here's how it could be used in a sentence with proper punctuation:
* "The patient presented with otitis media chronic unresponsive to treatment."
Here's why this punctuation works:
* Otitis media chronic unresponsive to treatment is a noun phrase describing the patient's condition.
* The phrase acts as the object of the verb "presented."
* The phrase is placed within quotation marks to indicate that it is a medical term.
If you are using this phrase in a different context, please provide more information, and I can help you with the punctuation!