Formal:
* Comment va-t-il ? (This is the most common and formal way to ask)
Informal:
* Comment il va ? (More informal, but still polite)
* Ça va ? (This is very informal and literally means "How is it going?", but can be used for "How are you?" or "How is he?")
* Il va bien ? (This literally means "Is he going well?" and is more informal than "Comment va-t-il?")
Note: You can also add a name after the phrase to clarify who you're asking about. For example:
* Comment va-t-il, Jean? (How is he, John?)
* Ça va, Pierre? (How are you doing, Peter?)
The best option will depend on the specific situation and your relationship with the person you're speaking to.