How do you say how are -familiar- in Spanish?

There's no single, direct translation of "how are -familiar-" in Spanish. This phrase is a bit unusual in English, and its meaning depends on the context.

Here are some possible ways to express similar ideas in Spanish, depending on the context:

1. "How are you doing?" (Informal)

* ¿Cómo estás? (If you're talking to someone you know well)

* ¿Qué tal? (Slightly more informal, often used as a greeting)

2. "How are you feeling?" (Informal)

* ¿Cómo te sientes?

3. "How are you getting along?" (Informal)

* ¿Cómo te va?

4. "How is it going?" (Neutral)

* ¿Cómo te va?

5. "How are you familiar with something?"

* ¿Qué tan familiarizado estás con...? (For example, "¿Qué tan familiarizado estás con este tema?" - "How familiar are you with this subject?")

6. "How well do you know...?"

* ¿Qué tanto conoces...? (For example, " ¿Qué tanto conoces a Juan?" - "How well do you know Juan?")

Please provide me with more context and I can give you a more accurate translation.