Here are some possible options, depending on the context:
* Yuck - The most straightforward and commonly used spelling.
* Ew - Shorter and often used in informal writing or text messaging.
* Ugh - Conveys a stronger feeling of disgust.
* Eww - A more emphatic version of "ew."
Ultimately, the best way to spell the sound "ewe" meaning "yuck" depends on the specific context and the desired level of formality.