It's a very strong and direct word, and it's important to use it carefully. It can be used in various contexts, like:
* In a literal sense: "He killed the animal." (彼は動物を殺した。)
* Figuratively: "This work is killing me." (この仕事は私を殺す。)
* In a more metaphorical way: "The news killed my hopes." (ニュースは私の希望を殺した。)
It's important to be aware of the context and the intended meaning when using this word.