Simple examples:
* The garden was bursting with a profusion of colorful flowers.
* The museum housed a profusion of ancient artifacts.
* The chef presented a profusion of delicious dishes.
More complex examples:
* Despite the profusion of information available online, it can be difficult to find reliable sources.
* The author's writing style is characterized by a profusion of metaphors and similes.
* The company's marketing campaign was met with a profusion of negative reviews.
Using "profusion" with different prepositions:
* The room was decorated with a profusion of candles.
* There was a profusion in the number of applicants for the job.
* She expressed her gratitude with a profusion of thanks.
Remember that "profusion" implies abundance and plenty, so choose your sentences carefully to convey that meaning.