Here's why:
* Preferable already implies a comparison and suggests something is more desirable than other options.
* Most implies a comparison between multiple options, which is already inherent in the word "preferable."
Instead of "most preferable," consider using:
* Most preferred (more common and natural)
* The most preferable (if you need to emphasize the superlative)
* Preferred (if the comparison is clear from context)
For example:
* Instead of: "This option is the most preferable."
* Try: "This option is the most preferred." or "This option is preferred."