General synonyms:
* Annihilate
* Demolish
* Ruin
* Wipe out
* Shatter
* Obliterate
* Eradicate
* Devastate
* Lay waste to
* Level
More specific synonyms:
* Disrupt: To break up the normal order or function of something.
* Corrupt: To damage the integrity or purity of something.
* Invalidate: To make something legally or officially ineffective.
* Disfigure: To damage the appearance of something.
* Break: To cause something to separate into pieces.
* Fracture: To break something into fragments.
* Spoil: To damage something so that it is no longer useful.
* Contaminate: To make something impure or poisonous.
* Subvert: To undermine or overthrow something.
The best synonym to use will depend on the specific situation and the intended meaning.