It's a common way to ask someone about their well-being and how they are feeling. It can be used in a casual conversation with friends or family, or in a more formal setting.
The phrase can also be interpreted in a more philosophical sense, asking about the meaning or nature of life itself.
Here are some possible translations of "Comment est la vie?" depending on the context:
* "How are you?" (most common)
* "How is life treating you?"
* "What is life like?"
* "What is the meaning of life?"
The meaning of the phrase will depend on the context and the speaker's intent.