* "Strengths" is often cited as the longest one-syllable word, but technically it has two syllables ("strengths").
* "Scourge" is a very strong contender, often pronounced as one syllable.
* "Through" is another word with a single sound, although some dialects might pronounce it with a slight "oo" sound.
Ultimately, the answer depends on how you're defining "syllable" and what pronunciation you're using.