Think of it this way: Something can be holy or not holy, there are no degrees of holiness.
However, if you want to express a difference in degrees of sacredness or reverence, you could use phrases like:
* More sacred/reverent
* Most sacred/reverent
* Highly sacred/reverent
* Deeply sacred/reverent
For example, you could say:
* "The cathedral is a more sacred place than the chapel."
* "The temple is considered the most sacred site in the religion."