Here are some examples of how "loco" is used as a prefix:
* Locomotive: An engine that moves itself and a train. It literally means "moving place."
* Location: The place where something is or happens.
* Local: Relating to a particular place or area.
* Locomotion: The act or process of moving from one place to another.
* Locoweed: A plant that can cause animals to become disoriented and act as if they are "crazy" (from the Spanish "loco").
Therefore, "loco" as a prefix signifies place, location, or movement.