Assis is a place name, referring to the city of Assis, in the state of São Paulo, Brazil.
Therefore, the surname De Assis likely indicates that the bearer's ancestors were from the city of Assis.
It's important to note that:
* "De" is a common Portuguese preposition meaning "of" or "from."
* The specific meaning of the name can vary slightly depending on the region and family history.
If you want to learn more about the specific meaning of De Assis for your family, consider researching your family history through genealogy resources.