It's used in various contexts, like:
* "Quiero probarlo de nuevo." (I want to try it again.)
* "Comenzaremos de nuevo." (We will start again.)
* "Volvió a la ciudad de nuevo." (He returned to the city again.)
* "Tenemos que empezar de nuevo." (We have to start anew.)
It's a versatile phrase that can be used to express repetition, restarting, or a return to a previous state.