Formal:
* Bien, gracias. Y la suya? (Well, thank you. And yours?)
* Está bien, gracias. (She is well, thank you.)
Informal:
* Bien, gracias. Y la tuya? (Well, thank you. And yours?)
* Está genial. (She's great.)
* Está un poco cansada. (She's a little tired.)
If you don't want to answer:
* No sé, no la he visto hoy. (I don't know, I haven't seen her today.)
* No quiero hablar de eso. (I don't want to talk about that.)
Remember to always be respectful and polite when answering this question.