Here's a breakdown:
* De: This is a preposition that can mean "of", "from", or "to" depending on context. In this case, it indicates direction.
* Irme: This is the reflexive form of the verb "ir" (to go), meaning "to go myself". It's used to emphasize that the speaker is the one going to Chicago.
* A: This is a preposition meaning "to".
* Chicago: This is the name of the city.
Here are some ways to use this phrase in a sentence:
* Estoy pensando en irme a Chicago el próximo año. (I'm thinking of going to Chicago next year.)
* Me voy a irme a Chicago mañana. (I'm going to leave for Chicago tomorrow.)
* Tengo que irme a Chicago por trabajo. (I have to go to Chicago for work.)
Let me know if you have any other Spanish phrases you'd like me to explain!