Formal:
* Avez-vous des frères ou des sœurs? (This is the most formal way to ask.)
Informal:
* Tu as des frères ou des sœurs? (You use "tu" with someone you know well)
* Vous avez des frères ou des sœurs? (You use "vous" with someone you don't know well, or when being polite)
* T'as des frères ou des sœurs? (This is very informal, and not appropriate for formal situations)
You can also use the following expressions:
* Êtes-vous enfant unique? (Are you an only child?)
* Avez-vous des siblings? (This is a more modern and less formal way to say it)
Remember that French grammar can be tricky! Make sure you're using the correct conjugation and word order depending on the context.