It generally indicates the process of creation, formation, or development.
Here are some examples:
* Pathogenesis: The development of disease.
* Biogenesis: The origin of life from non-living matter.
* Ontogenesis: The development of an individual organism from a fertilized egg.
* Cosmogenisis: The formation of the universe.
* Telegenesis: The development of a specific goal or purpose.
So, when you see "-genesis" in a word, it tells you that the word is about the beginning or development of something.