Here are some examples:
* "They are so comfortable!" (referring to a pair of pants)
* "I love the way they look on you." (referring to a dress)
* "Where did you get them?" (referring to a pair of shoes)
However, sometimes it's better to use a more specific pronoun like "it" if you are referring to a single item of clothing:
* "I bought it on sale." (referring to a specific shirt)
Ultimately, the best pronoun to use depends on the context and what you are trying to convey.