Formal/Romantic:
* Tu es l'unique. (You are the unique one.)
* Tu es mon unique amour. (You are my unique love.)
Informal/Romantic:
* Tu es la seule pour moi. (You are the only one for me.)
* Tu es ma seule et unique. (You are my one and only.)
Informal/Playful:
* Tu es mon tout. (You are my everything.)
* Tu es le meilleur. (You are the best.)
More literally:
* Tu es le/la seul(e) et unique. (You are the only and unique.)
The best choice depends on the context and your relationship with the person.