For physical limbs:
* Limb: This is the most direct synonym.
* Appendage: This emphasizes the attached nature of the limb.
* Hand/Foot/Arm/Leg: Specific terms for different extremities.
For the furthest point or limit:
* End: This is a general synonym for the furthest point.
* Edge: This implies a boundary or limit.
* Limit: This focuses on the restriction or boundary.
* Extreme: This highlights the furthest point from the center or norm.
* Ultimate: This suggests the highest degree or final point.
For a state of great difficulty or danger:
* Crisis: This describes a critical or unstable situation.
* Peril: This implies a threat or danger.
* Desperation: This refers to a state of hopelessness and urgency.
* Dire straits: This describes a very difficult or dangerous situation.
For extreme political views:
* Radical: This describes someone who holds extreme political views.
* Fanatic: This refers to someone who is excessively devoted to a cause.
* Zealot: This describes someone who is intensely and uncritically enthusiastic about a cause.
Please provide me with more context, and I can suggest a more specific synonym.