* Anti-: This prefix means "against" or "opposite."
* Ochos: This word refers to a "way" or "path."
Therefore, the literal meaning of Antioch is "opposite the way" or "against the way."
However, this literal meaning doesn't fully capture the historical significance of the name. The city of Antioch, founded by Seleucus I Nicator in 300 BC, was strategically located at the crossroads of major trade routes. It became a bustling center of commerce and culture, earning the title "Queen of the East."
Therefore, while "against the way" might refer to its geographic position or its potential opposition to some other city or path, the name ultimately represents a city that was highly influential and well-connected, serving as a hub for the exchange of ideas, goods, and people.