When "comprise" means "to include":
* Exclude
* Omit
* Leave out
* Eliminate
* Discard
When "comprise" means "to be made up of":
* Divide
* Separate
* Disassemble
* Break down
* Decompose
When "comprise" means "to make up a whole":
* Dissolve
* Disintegrate
* Fragment
* Scatter
* Disperse
The best antonym will depend on the specific meaning of "comprise" in your sentence.