Here are some antonyms for "shrine" based on different interpretations:
* If "shrine" refers to a sacred place of worship:
* Desecration: This is the opposite of something sacred.
* Profanity: This implies treating something holy with disrespect.
* Irreverence: This means lacking respect for something sacred.
* If "shrine" refers to a place dedicated to a memory:
* Forgetting: This is the opposite of remembering and honoring.
* Neglect: This implies not taking care of something important.
* If "shrine" refers to a place of pilgrimage:
* Seclusion: This implies being isolated and inaccessible.
* Desolation: This means being barren and devoid of life.
To give you the most appropriate antonym, please provide more context about how you are using the word "shrine".