For the opening in the face:
* Nose: This is a direct contrast, being the other prominent opening on the face.
* Ear: Another contrasting facial opening.
* Eye: While not technically an opening, it is another sensory organ on the face.
For the act of speaking:
* Silence: The absence of speech.
* Writing: A different form of communication.
* Thinking: The process of formulating ideas without expressing them verbally.
For the opening of a container or object:
* Closure: The opposite of opening.
* Lid: A physical barrier that covers an opening.
For the entrance or outlet of a river:
* Source: The origin of the river, the opposite of its outlet.
To choose the best antonym, consider the specific meaning of "mouth" in your context.