Size/Quantity:
* Big
* Large
* Huge
* Vast
* Immense
* Extensive
* Great
* Much
* Many
Importance:
* Significant
* Major
* Important
* Great
* Substantial
Age:
* Old
* Mature
* Elderly
Other:
* Much
* Many
* Abundant
* Plenty
* Sufficient
* Enough
Example:
* "She has a little dog." - Antonym: "She has a big dog."
* "There are only a little number of people here." - Antonym: "There are many people here."
* "That's a little problem." - Antonym: "That's a big problem."
It's important to consider the specific meaning of "little" in your context to choose the most appropriate antonym.