General Antonyms:
* End
* Conclusion
* Termination
* Destination
* Result
* Outcome
Specific Antonyms, depending on context:
* Destination: If "origin" refers to a starting point, the antonym could be "destination".
* Cause: If "origin" refers to the source of something, the antonym could be "effect".
* Birth: If "origin" refers to the beginning of life, the antonym could be "death".
The best antonym for "origin" will depend on the specific context in which you are using it.