Empathy and pity:
* That's so sad for him/her.
* Poor thing.
* I feel so sorry for him/her.
* It's heartbreaking to see.
Concern and worry:
* I'm worried about him/her.
* I hope he/she's okay.
* He/she needs help.
Sympathy and understanding:
* He/she's having a tough time.
* I can relate to how he/she feels.
* It's not easy for him/her.
A more colloquial option:
* That's rough.
Ultimately, the best English translation will depend on the specific situation and the tone you're trying to convey.