Formal:
* நீ என்ன பண்றீங்க? (Nee enna panreeng?)
* நீ என்ன செய்றீங்க? (Nee enna seireeng?)
Informal:
* என்ன பண்றீங்க? (Enna panreeng?)
* என்ன செய்றீங்க? (Enna seireeng?)
* என்ன பண்ணுறீங்க? (Enna pannureeng?)
* என்ன செய்றீங்க? (Enna seireeng?)
More Casual:
* என்ன பண்ற? (Enna pannra?)
* என்ன செய்ற? (Enna seira?)
Remember:
* The formal versions use the honorific "ங்க" (ng) at the end of the verb.
* The informal versions omit the honorific.
* The more casual versions are used with friends and family.
It's also important to note that Tamil, like any language, has many nuances. The best way to choose the right phrase is to consider the situation and the person you are talking to.