Here are some English phrases that capture the essence of "nagsasawa":
* Tired of
* Fed up with
* Sick of
* Exhausted by
* Disillusioned with
* Having enough of
* Wanting a change from
The most appropriate translation will depend on the specific context of the phrase.
For example:
* Nagsasawa na ako sa trabaho ko. (I'm tired of my job.)
* Nagsasawa na ako sa ugali niya. (I'm fed up with his behavior.)
* Nagsasawa na ako sa paghihintay. (I'm tired of waiting.)