Formal:
* Comment va votre frère? (This is the most formal way to ask.)
Informal:
* Comment va ton frère? (If you know the person well and your brother is male.)
* Comment va ta sœur? (If you know the person well and your brother is female.)
More informal:
* Ça va ton frère? (If you're very casual with the person.)
* Comment il va, ton frère? (If you're asking about a specific brother.)
It's important to choose the right level of formality based on your relationship with the person you're talking to.