Formal:
* Que cherchez-vous? (pronounced: kuh sher-shay voo)
Informal:
* Tu cherches quoi? (pronounced: too sher shuh kwah) - You are looking for what?
More colloquial:
* C'est quoi que tu cherches? (pronounced: say kwah kuh too sher shuh) - What is it that you are looking for?
The choice between these options depends on the level of formality you need to maintain. You would use the formal form when speaking to someone you don't know well, or in a professional setting. The informal forms are appropriate for friends and family.