Simple examples:
* The family feud had estranged them for years.
* His harsh words estranged his friends.
* Years of neglect had estranged her from her children.
More complex examples:
* The political turmoil estranged the two nations, once close allies.
* The constant arguing and criticism estranged him from his wife.
* The rapid modernization of the city estranged many of its older residents.
In a literary context:
* The war had estranged him from his homeland, leaving him feeling adrift and alone.
* Her betrayal estranged him from the only person he had ever truly trusted.
Note: "Estranged" can be used as an adjective or a verb. When used as a verb, it can be either active or passive (e.g., "He estranged his family" vs. "The family was estranged").