If you mean "not interesting", the opposite is:
* Aburrido/a (boring)
* Insípido/a (tasteless, dull)
* Monótono/a (monotonous)
* Desinteresante (uninteresting)
If you mean "uninteresting" in a specific way, you could use:
* Insignificante (insignificant)
* Trivial (trivial)
* Irrelevante (irrelevant)
Example:
* "La película era interesante." (The movie was interesting.)
* "La película era aburrida." (The movie was boring.)
The best opposite for "interesante" will depend on the specific situation and what you want to emphasize.