General:
* Competent
* Proficient
* Expert
* Able
* Talented
* Dexterous
* Adroit
* Masterful
More specific:
* Artisan (for skilled craftspeople)
* Craftsman/Craftswoman (for skilled workers)
* Virtuoso (for highly skilled musicians or artists)
* Adept (for someone who has learned to do something well)
* Accomplished (for someone who has achieved a high level of skill)
The best synonym for "skilled" depends on the specific situation and the nuance you want to convey.