General terms:
* Incompetence
* Ineptness
* Clumsiness
* Unskillfulness
* Unpreparedness
* Inexperience
* Amateurism
* Unfamiliarity
* Lack of proficiency
* Lack of expertise
More specific terms:
* Awkwardness (for physical skills)
* Blundering (for mistakes)
* Fumbling (for handling objects)
* Inefficiency (for work)
* Ignorance (for knowledge)
* Untidiness (for organization)
Figurative terms:
* Greenhorn (for someone new to something)
* Rookie (for someone new to something)
* Lacks the knack (for a particular ability)
* All thumbs (for someone clumsy)
The best word will depend on the specific situation and the nuance you want to convey.