"കുഴപ്പമുണ്ടോ?" (kuzhappamundo?)
However, this phrase implies that the person is mentally unstable or not in their right mind.
Here are some other ways to express "are mad" in Malayalam depending on the context:
* "കോപം വന്നിരിക്കുന്നു" (kopaṁ vannirikkunnu) - "are angry"
* "ക്ഷുഭിതനാണ്" (kṣubhitanaanu) - "are furious"
* "അസഹനക്ഷമനാണ്" (asahaṇakṣamanāṇu) - "are intolerant"
* "ചൊറിച്ചിൽ" (choricchil) - "are irritated"
* "വളരെ ദേഷ്യം വന്നു" (valare deṣyam vannu) - "are very angry"
The best way to say "are mad" in Malayalam will depend on the specific situation and the level of anger you are trying to convey.