Here are some examples:
Not capitalized:
* The northern region of the country is experiencing a drought.
* The region is known for its beautiful beaches.
Capitalized:
* The Great Lakes Region is a popular tourist destination.
* The South Region is famous for its barbecue.
Important note: "Region" should be capitalized when it is used as part of a formal name, such as the name of a government agency or a geographical area with a specific name.