The main languages spoken in the Cagayan Valley Region are:
* Ilocano: This is the dominant language in the region, spoken by the majority of the population.
* Tagalog: This is the national language of the Philippines and is also widely spoken in the region.
* Ibanag: This language is spoken by the Ibanag people, who are indigenous to the northeastern part of the region.
* Gaddang: This language is spoken by the Gaddang people, who are indigenous to the central part of the region.
* Yogad: This language is spoken by the Yogad people, who are indigenous to the southern part of the region.
Other languages spoken in the region include English, which is widely used in education and government, and other local dialects.