No space is needed between the letters.
However, there is an exception when it is used as an adjective. In that case, it is written as U.S. without periods.
For example:
* U.S. history (adjective)
* The U.S. is a large country. (noun)
No space is needed between the letters.
However, there is an exception when it is used as an adjective. In that case, it is written as U.S. without periods.
For example:
* U.S. history (adjective)
* The U.S. is a large country. (noun)