How do you say he has 2 sisters and one brother in french?

There are a few ways to say this in French, depending on the emphasis you want to put on:

Emphasis on the number of siblings:

* Il a deux sœurs et un frère. (This is the most literal translation and the most common way to say it.)

Emphasis on the specific type of siblings:

* Il a deux sœurs et un frère. (This is the same as above, but focuses on the sisters and brother.)

Emphasis on the fact that he has siblings:

* Il a des frères et sœurs, deux sœurs et un frère. (This emphasizes that he has siblings in general and then specifies the number of each.)

Using a relative clause:

* Il a deux sœurs, qui sont ses seules sœurs, et un frère. (This emphasizes that he has only two sisters and one brother.)

You can choose the phrase that best suits the context of your conversation.