* Kupunawahine: This is the most general term for grandmother. It literally means "old woman" and can refer to any woman who is a grandmother, regardless of her relationship to you.
* Kūpuna: This is a more general term for "elder" or "ancestor" and can be used to refer to both grandmothers and grandfathers.
* Tūtū: This is a more specific term for grandmother on your mother's side.
* Kūpuna wahine: This term is used to distinguish a grandmother from a grandfather. "Wahine" means "woman."
* Kūpuna kāne: This term is used to distinguish a grandfather from a grandmother. "Kāne" means "man."
The best way to say "grandmother" in Hawaiian will depend on the specific relationship and the context of the conversation.