* Basque: Spoken in the Basque Country, straddling the border between Spain and France, Basque has no known genetic relationship to any other language in the world. It is considered a language isolate.
* Burushaski: Spoken in the Hunza Valley in northern Pakistan, Burushaski also has no known genetic relationship to any other language. It is also considered a language isolate.
It's important to note that while these languages are considered language families all their own, they do have some similarities with other language families, but these similarities are thought to be due to contact and borrowing rather than genetic relationship.