Formal/Literal:
* Mon école est grande. (This is the most direct translation and means "My school is big" in the literal sense.)
Informal/Emphasis on size:
* Mon école est immense. (This emphasizes the school's size and translates to "My school is immense.")
* Mon école est énorme. (This also emphasizes size and translates to "My school is enormous.")
Informal/Emphasis on many students:
* Il y a beaucoup d'élèves dans mon école. (This literally means "There are a lot of students in my school" and implies that the school is big because it has many students.)
Descriptive:
* Mon école est un grand bâtiment. (This means "My school is a big building" and focuses on the physical size of the building.)
The best choice will depend on the context of your conversation.