Formal:
* 妹妹 (mèimei): This is the most common and neutral way to say "little sister". It's suitable for most situations, even formal ones.
Informal:
* 小妹 (xiǎomèi): This is a more informal way to say "little sister". It's often used by older siblings or close friends.
* 妹 (mèi): This is the most informal way to say "little sister" and is usually used between siblings who are very close.
Note:
* The choice of which term to use depends on your relationship with the person you're talking about and the context of the conversation.
* In some cases, you might also use "小妹" as a respectful way to address a young woman.