Formal:
* Combien avez-vous de frères et sœurs? (How many brothers and sisters do you have?)
* Combien de frères et sœurs avez-vous? (How many brothers and sisters do you have?)
Informal:
* Combien de frères et sœurs tu as? (How many brothers and sisters do you have?)
* Tu as combien de frères et sœurs? (How many brothers and sisters do you have?)
You can also use separate questions for brothers and sisters:
* Combien de frères as-tu? (How many brothers do you have?)
* Combien de sœurs as-tu? (How many sisters do you have?)
Remember to adjust the verb conjugation based on the person you are talking to (formal "vous" or informal "tu").