* Adept
* Skilled
* Proficient
* Competent
* Talented
* Gifted
* Able
* Capable
* Dexterous (if it's a physical task)
* Savvy (if it's a mental task)
* Fluent (if it's a language or communication skill)
* Natural
* At ease
* A breeze (informal)
The specific word you choose will depend on the context and the level of ease you are trying to convey.