* Formal: "The company will proceed with the project irrespective of the recent market fluctuations."
* Casual: "I'm going to the party irrespective of whether or not my friends are going."
* Emphasis: "You should always be kind to others, irrespective of their social status."
* With a prepositional phrase: "We will continue our research irrespective of the challenges we may face."
* With a clause: "The concert will go on irrespective of whether it rains."
Irrespective means "without regard to" or "not considering." It emphasizes that something will happen or be done regardless of other factors.