* Self-destructive: Causing harm to oneself.
* Highly destructive: Very destructive.
* Overly destructive: Excessively destructive.
* Anti-destructive: Opposing destruction.
* Counter-destructive: Working against destruction.
* Pre-destructive: Existing or happening before destruction.
* De-destructive: Removing or reducing destruction.
The best prefix to use will depend on the specific context you are writing in.