Here are a few examples of topic sentences depending on your focus:
Focus on effects:
* The widespread use of prescription opioids has led to a devastating addiction crisis in the United States.
* Recreational drug use can have a profound impact on both physical and mental health.
* The long-term effects of marijuana use on the developing brain remain a subject of debate.
Focus on societal impact:
* The criminalization of drug use has created a system that disproportionately affects marginalized communities.
* The war on drugs has had a devastating impact on communities of color.
* The legal and ethical implications of drug legalization are complex and multifaceted.
Focus on policy:
* Drug policy reform is essential to address the ongoing public health crisis.
* The current approach to drug treatment in the United States is ineffective and needs to be reevaluated.
* Investing in prevention and harm reduction programs is crucial to mitigating the negative consequences of drug use.
Remember to choose a topic sentence that reflects your specific argument and the direction you want to take your writing.